Vlasova Laboratory

Dr. Anastasia Vlasova
Food Animal Health Research Program

Food Animal Health – OARDC
Wooster, OH 44691
Phone: 330-263-3740
Fax: 330-263-3760
Email: vlasova.1@osu.edu

Areas of Expertise

Animal Health, Veterinary Epidemiology, Infectious Disease Epidemiology, Veterinary Diagnostics, Veterinary Preventive Medicine, Veterinary Microbiology, Veterinary Infectious Diseases, Veterinary Virology, Veterinary Vaccine Production

Research Interests

My main research interests include: 1) Innate immunity and pathogenesis of enteric viruses; 2) Interactions among host, pathogens, microbiome and micro/macronutrients, and 3) Development of interventions for human and swine enteric viral diseases using the neonatal gnotobiotic pig as a model. Another focus area is the molecular characterization of emerging and re-emerging animal, human and zoonotic (enteric and respiratory) viruses to understand their molecular evolution and interspecies transmission and to develop optimal diagnostic tools and control measures.

Laboratory Personnel

Selected Publications

Shao, L., Fischer, D.D., Kandasamy, S., Rauf, A., Langel, S.N., Wentworth, D.E., Stucker, K.M., Halpin, R.A., Lam, H.C., Marthaler, D., Saif, L.J., Vlasova, A.N. 2015. Comparative in vitro and in vivo studies of porcine rotavirus G9P[13] and human rotavirus Wa G1P[8]. J Virol. 2015 Oct 14. pii: JVI.02401-15. [Epub ahead of print]
Vlasova, A.N., Kandasamy, S., Chattha, K.S., Rajashekara, G., Saif, L.J. 2015. Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species. Veterinary Immunology and Immunopathology. (In press).
Hu, H., Jung, K., Vlasova, A.N., Chepngeno, J., Lu, Z., Wang, Q., Saif, L.J. 2015. Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States. J Clin Microbiol.; 53(5):1537-48.
Lin, C.-M., Gao, X., Oka, T., Vlasova, A.N., Esseili, M.A., Wang, Q., Saif, L.J. 2015. Antigenic Relationships among Porcine Epidemic Diarrhea Virus and Transmissible Gastroenteritis Virus Strains. Vet Microbiol. 2015 Mar;89(6):3332-42.
Amimo, J.O., Junga, J.O., Ogara, W.O., Vlasova, A.N., Njahira, M.N., Maina, S., Okoth, E.A., Bishop, R.P., Saif, L.J., Djikeng, A. 2014. Detection and genetic characterization of porcine group A rotaviruses in asymptomatic pigs in smallholder farms in East Africa: Predominance of P[8] genotype resembling human strains. Vet Microbiol. 2014 Dec 10.
Kandasamy, S., Chattha, K.S., Vlasova, A.N., Esseili, M., Siegismund, C., Liu, Z., Rajashekara, G., Saif, L.J. 2014. Co-colonization of Lactobacillus and Bifidobacterium probiotics augment B cell responses to human rotavirus vaccine in neonatal gnotobiotic pig model. Gut Microbes. 2014 Sep 1:0.
Vlasova, A., Marthaler, D., Wang, Q., Culhane, M.R., Rossow, K.D., Rovira, A., Collins, J., Saif, L.J. 2014. Distinct Characteristics and Complex Evolution of PEDV Strains, North America, May 2013–February 2014. Emerging Infectious Diseases, 20(10):1620-8.
Oka, T., Saif, L.J., Marthaler, D., Esseili, M.A., Meulia, T., Lin, C.M., Vlasova, A.N., Jung, K., Zhang, Y., Wang, Q. 2015. Cell culture isolation and sequence analysis of genetically diverse US porcine epidemic diarrhea virus strains including a novel strain with a large deletion in the spike gene.
Vet Microbiol. 2014 Oct 10; 173(3-4):258-69.
Kumar, A., Vlasova, A.N., Liu, Z., Chattha, K.S., Kandasamy, S., Esseili, M., Zhang, X., Rajashekara, G., Saif, L.J. 2014. In vivo gut Transcriptome Responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in Neonatal Gnotobiotic Piglets. Gut Microbes. 2014 Jan 22; 5(2):152-64.
Kandasamy, S., Chattha, K.S., Vlasova, A.N., Saif, L.J. 2014. Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in a neonatal gnotobiotic pig model. Vaccine. 2013 Dec 29. pii: S0264-410X(13)01770-2. doi: 10.1016/j.vaccine.2013.12.039. [Epub ahead of print].PMID: 24380684
Amimo, J.O., Okoth, E., Junga, J.O., Ogara, W.O., Njahira, M.N., Wang, Q., Vlasova, A.N., Saif, L.J., Djikeng, A. 2013. Molecular detection and genetic characterization of kobuviruses and astroviruses in asymptomatic local pigs in East Africa. Arch Virol. 2013 Dec 11. 159(6):1313-9.
Chattha, K.S., Kandasamy, S., Vlasova, A.N., Saif, L.J. 2013. Vitamin a deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model. PLoS One. 2013 Dec 2;8(12):e82966.
Vlasova, A.N., Chattha, K.S., Kandasamy, S., Rajashekara, G., Saif, L.J. 2013. Lactobacillus rhamnosus (GG) and Bifidobacterium lactis (Bb12) colonization promotes intestinal homeostasis by modulating innate immune responses to human rotavirus in neonatal gnotobiotic pigs; 8(10):e76962.
Chattha, K.S., Vlasova, A.N., Kandasamy, S., Liu, Z., Rajashekara, G., Saif, L.J. 2013. Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model. J Immunol.; 191(5):2446-56.
Book Chapters:
Vlasova, A.N., Kandasamy, S., Saif, L.J. 2015. Gnotobiotic neonatal pig model of rotavirus infection and disease. Viral Gastroenteritis: Molecular biology, pathogenesis, epidemiology and vaccine development edited by Lennart Svensson, Ulrich Desselberger, Harry B Greenberg, Mary K Estes, Elsevier Academic Press, 2015. (In press)
Kandasamy, S., A. Kumar, G. Rajashekara, A. Vlasova, and L.J. Saif. 2015. In: Probiotics in Children. Probiotics for immunomodulation and treatment of immunological disorders in children: Evaluation in a gnotobiotic animal model. (M. Manfredi and G. Luigi de’Angelis , eds). Nova Science Publishers, New York. (In press)
Hodgins, D.C., Chattha, K.S., Vlasova, A.N., Parreno, V., Corbeil, L.B., Renukaradhya, G.J., Saif, L.J. 2014: Mucosal veterinary vaccines: Comparative Vaccinology. Mucosal Immunology (4th edn), Academic Press.
Azevedo MP, Vlasova AN, Saif LJ. 2014. Evaluation of human rotavirus VLP vaccines in neonatal gnotobiotic pigs. In: Virus-like Particles in Vaccine Development. Unitec House, 2 Albert Place, London N3 1QB, UK (Future Medicine Ltd) 2014. Pages 50-67.
Vlasova, A.N. and Saif, L.J. 2013. Biological aspects of the interspecies transmission of coronaviruses. In: Viral Infections and Global Change, First Edition. Edited by Sunit K. Singh. © 2014 John Wiley & Sons, Inc. pp. 393-418.
Hasoksuz, M., Vlasova, A., Saif, L.J. 2008. Detection of Group 2a Coronaviruses with Emphasis on Bovine and Wild Ruminant Strains. Virus Isolation and Detection of Antibody, Antigen, and Nucleic Acid. In: SARS and Other Coronaviruses, Methods in Molecular Biology, (D. Cavanagh, ed.); 454(1): 43-59.


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