Dr. Renukaradhya Gourapura
Food Animal Health Research Program
Food Animal Health – OARDC
Wooster, OH 44691
Animal Health, Veterinary Epidemiology, Infectious Disease Epidemiology, Veterinary Diagnostics, Veterinary Preventive Medicine, Veterinary Microbiology, Veterinary Infectious Diseases, Veterinary Virology, Veterinary Vaccine Production
My laboratory research focus is on mucosal immunology of food animals infected with infectious and zoonotic diseases. Unlike systemic delivery, mucosal delivery of potent vaccines is gaining increased attention to increase the breadth of cross-protective immunity against infections which cause severe disease at mucosal sites. We are interested to understand mucosal immune responses in pigs and other species of food animals to viral and bacterial infections, and to vaccines delivered directly to mucosal sites. Currently, we are evaluating potent bacterial-based and synthetic adjuvants, which were proven effective and safe in other species of animals to use in food animals. Our ongoing studies are aimed to potentiate the cross-protective efficacy of modified live virus and biodegradable nanoparticle-entrapped inactivated virus vaccines of porcine reproductive and respiratory syndrome (PRRS) virus and influenza virus, coadministered intranasally with a potent adjuvant to pigs. Other focus of our study is to understand host-pathogen interactions, viral pathogenesis, and immune evasion mechanisms in food animals infected with viral and bacterial pathogens; and developing a pig model for biomedical research.